GPR81 agonists

GPR81 agonists improve muscle regeneration in mice.

“we observed significant improvement in muscle regeneration and overall health of progeric mice that were treated with GPR81 agonists.”

Animalsprogeric miceskeletal muscle

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging cell·1 Aug 2026

GPR81 agonists decrease lipid accumulation in mouse cells.

“treatment of senescent myoblasts with GPR81 agonists enhanced lipid oxidation, leading to a decrease in lipid accumulation”

Cellssenescent myoblastsmyoblast

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging cell·1 Aug 2026