Forskolin

1. Forskolin prevents phenotypic heterogeneity in human cells.

   “replacing the Rho-associated coiled-coil kinase (ROCK) inhibitor Y27632 with forskolin, which enhances cell-cell and cell-substrate adhesion, facilitated uniform maturation of confluent hiPS-RPE cells on a laminin-332-coated liquid-liquid interface.”

   Cellsconfluent cells on laminin-332-coated liquid-liquid interface

   Cultivation at a liquid-liquid interface prevents phenotypic heterogeneity of human induced pluripotent stem-derived retinal pigment epithelial cells

   New biotechnology·14 Oct 2025

1. Forskolin impairs ventricular histology in rats.

   “FSK treatment from 1 to 7 months resulted in limited functional benefits and worsened ventricular histology in the heart.”

   Animalsin DMD rats6 months

   Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy

   Skeletal muscle·7 May 2025

1. Forskolin decreases inflammation in rats.

   “FSK also modulated inflammation by reducing pro-inflammatory macrophages and promoting a shift to a restorative phenotype.”

   Animalsin acute muscle injury model in DMD rats

   Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy

   Skeletal muscle·7 May 2025

More on Inflammation

1. Forskolin decreases cellular senescence in rats.

   “Long-term FSK treatment in the acute injury model enhanced muscle regeneration, increased MuSC proliferation, and reduced senescence.”

   Animalsin acute muscle injury model in DMD rats

   Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy

   Skeletal muscle·7 May 2025

More on Cellular senescence

1. Forskolin decreases fibrosis in rats.

   “FSK treatment significantly improved muscle histology and reduced fibrosis in both uninjured and injured DMD muscles by decreasing the number of FAPs.”

   Animalsin uninjured and injured DMD muscles

   Forskolin treatment enhances muscle regeneration and shows therapeutic potential with limitations in Duchenne muscular dystrophy

   Skeletal muscle·7 May 2025