Fluoxetine

2 papers3 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funders: National Center for Complementary and Alternative Medicine and 2 more

Animals1
Model organisms1

Outcomes

3

Lifespan

upin worms1

1 study

Fluoxetine extends lifespan in worms.
“We also found that fluoxetine increased thermal stress resistance and extended life span.”
Model organisms
Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
Neuropharmacology24 Apr 2010

Aβ oligomers

downin worms1

1 study

Fluoxetine decreases Aβ oligomers in worms.
“delayed Abeta-induced paralysis in the C. elegans model of Abeta toxicity by reducing Abeta oligomers.”
Model organismsin C. elegans model of Abeta toxicity
Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
Neuropharmacology24 Apr 2010

More on Aβ oligomers

Paralysis

downin worms1

1 study

Fluoxetine protects against paralysis in worms.
“We found that the antidepressant fluoxetine, a selective serotonin reuptake inhibitor, significantly delayed Abeta-induced paralysis”
Model organismsin C. elegans model of Abeta toxicity
Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
Neuropharmacology24 Apr 2010

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