Fatty acids

4 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute of General Medical Sciences and 5 more

Humans1
Model organisms1

Outcomes

Cellular senescence

upin reviews1

1 study

Fatty acids induce cellular senescence.
“lipid overload has emerged as a relevant metabolic stress capable of inducing senescence across multiple cell types and tissues”
Reviewduring lipid overload
Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload
Ageing research reviews27 Mar 2026

Associations

Chromatin and 3D genome organisation

mixedin reviews1

1 study

Fatty acids are associated with chromatin and 3D genome organisation.
“fatty acid-driven metabolic alterations reshape chromatin dynamics to promote and stabilize cellular senescence”
Reviewin the context of obesity and high-fat diets
Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload
Ageing research reviews27 Mar 2026

More on Chromatin and 3D genome organisation