CDK4
Gene2 papers1 findingHGNC 1773NCBI Gene 1019Taxon 9606
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more1 of 1 trial sponsored by developers of drugs on it
- Cells2
Interventions
1INTERLEUKIN-1BETA
downin human cells1
1 study
INTERLEUKIN-1BETA
downin human cells1
INTERLEUKIN-1BETA decreases CDK4 in human cells.
Cellsin primary human articular chondrocytes10 ng/mLup to four days
Proteomic Dynamics Reveal Cell-Cycle and Rho GTPase Remodeling Associated with Transient Senescence Traits in Human Chondrocytes During Sustained IL-1β Signaling · Cells · 8 Aug 2026