CMS121

1. CMS121 improves cognitive function.

   “we identified the fisetin derivative CMS121 as a potent neuroprotective molecule that is able to maintain cognitive function in multiple pre-clinical models of AD”

   Reviewin multiple pre-clinical models of AD

   CMS121, a Novel Drug Candidate for the Treatment of Alzheimer's Disease and Age-Related Dementia

   Journal of Alzheimer's disease : JAD·Jan 1, 2024

1. CMS121 improves motor function in mice.

   “In both models, we found a slowing of motor dysfunction”

   Animalsin R6/2 and YAC128 mouse models of HD

   CMS121 Partially Attenuates Disease Progression in Mouse Models of Huntington's Disease

   Molecular neurobiology·Oct 21, 2023

1. CMS121 extends lifespan in mice.

   “In both models, we found a slowing of motor dysfunction and an increase in median life span.”

   Animalsin R6/2 and YAC128 mouse models of HD

   CMS121 Partially Attenuates Disease Progression in Mouse Models of Huntington's Disease

   Molecular neurobiology·Oct 21, 2023

1. CMS121 increases synapses in mice (18.4 vs 15.7 per IHC, p = 0.014).

   “Immunohistochemistry showed a significantly lower synapse count per IHC in the control group (15.7) compared to the CMS121 group (18.4), p = 0.014.”

   Animalscochleafemales

   Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121

   Journal of molecular neuroscience : MN·Apr 25, 2023

More on Synapses

1. CMS121 decreases hearing impairment in mice (39.8 vs 56.5 at 12 kHz, 43.8 vs 64.8 at 16 kHz).

   “At 13 weeks of age, the control group had significantly worse hearing thresholds at 12 kHz (56.5 vs. 39.8, p = 0.044) and 16 kHz (64.8 vs. 43.8, p = 0.040) compared to the CMS121 group.”

   Animalsfemales

   Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121

   Journal of molecular neuroscience : MN·Apr 25, 2023

1. CMS121 decreases kidney damage in mice.

   “Urine markers of kidney damage were improved, as evidenced by lower urinary levels of NGAL, clusterin, and albumin.”

   Animalsin db/db micedietkidney6 months

   The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

   International journal of molecular sciences·Apr 6, 2023

1. CMS121 decreases inflammation in mice.

   “Markers of liver inflammation, including NF-κB, IL-18, caspase 3, and C reactive protein, were lowered by the CMS121 treatment.”

   Animalsin db/db micedietliver6 months

   The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

   International journal of molecular sciences·Apr 6, 2023

More on Inflammation

1. CMS121 decreases HbA1c in mice.

   “Improved glucose tolerance and reduced HbA1c and insulin levels were also seen.”

   Animalsin db/db micediet6 months

   The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

   International journal of molecular sciences·Apr 6, 2023

More on HbA1c

1. CMS121 decreases body weight in mice (-5%).

   “No changes were observed in food and oxygen consumption, body mass, or locomotor activity compared to control db/db mice, but a 5% reduction in body weight was noted.”

   Animalsin db/db micediet6 months

   The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

   International journal of molecular sciences·Apr 6, 2023

1. CMS121 improves kidney function in mice.

   “Both compounds improved physiological markers for brain and kidney function.”

   Animalsin SAMP8 micekidney

   Geroprotective effects of Alzheimer's disease drug candidates

   Aging·Feb 6, 2021