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Synapses

Biomarker

4 papers3 findings

  • Humans1
  • Animals3

Interventions

3

Aged gut microbiota transplantation

downin mice1

1 study

  1. Aged gut microbiota transplantation decreases synapses in mice.

    “fecal microbiota of naturally aged mice successfully transferred cognitive impairment and hippocampal synapse loss to young recipients.”

    Animalsfecal microbiota transplantation from aged micehippocampus

    Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice

    Aging cellApr 12, 2025

More on Aged gut microbiota transplantation

CMS121

upin mice1

1 study

  1. CMS121 increases synapses in mice (18.4 vs 15.7 per IHC, p = 0.014).

    “Immunohistochemistry showed a significantly lower synapse count per IHC in the control group (15.7) compared to the CMS121 group (18.4), p = 0.014.”

    Animalscochleafemales

    Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121

    Journal of molecular neuroscience : MNApr 25, 2023

More on CMS121

Caloric restriction

no changein rats1

1 study

  1. Caloric restriction has no effect on synapses in rats.

    “The results indicate that synapses are maintained across lifespan in both AL and CR rats.”

    Animalsin AL and CR rats across lifespandentate gyrus

    Effects of aging and caloric restriction on dentate gyrus synapses and glutamate receptor subunits

    Neurobiology of agingApr 11, 2007

More on Caloric restriction

Funding

15 grants since 2017

National Institute on AgingUS$3.7mNational Institute of Neurological Disorders and StrokeUS$4.1mNational Institute of Biomedical Imaging and BioengineeringUS$638.6k

Latest

Nov 2025: 9Dec 2025: 25Jan 2026: 9Feb 2026: 10Mar 2026: 7Apr 2026: 14May 2026: 5Jun 2026: 10Jul 2026: 7Aug 2026: 9Sep 2026: 7Oct 2026: 5117 in 12 months
Nature Neuroscience

Boosting a secreted enzyme protected memory in aging mice

Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.Experiments in mice suggested that an enzyme released by nerve cells helps compensate for age-related brain changes and preserve memory.

Mouse studyMechanisms
Paper
Nature Aging

Suppressing a stem cell enzyme improved cognition in aging mice

Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.

Mouse studyMechanisms
Paper
Stem Cell Reports

Donor light-sensing cells may connect in a non-human primate

A substantial share of donor cells survived 20 weeks after scaffold delivery to a non-human primate retina, with signs of possible connections to host cells.A substantial share of donor cells survived 20 weeks after scaffold delivery to a non-human primate retina, with signs of possible connections to host cells.

Experiments in animalsInterventions
Paper
bioRxiv

Voluntary running shows limited neuroprotection in mice

In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.In 5xFAD mice, 16 weeks of voluntary wheel running altered fat tissue but produced modest hippocampal changes and failed to improve amyloid pathology or memory.

Preprint: experiments in miceInterventions
Paper
bioRxiv

Rapid auditory readout tracks nerve loss in gerbils

A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.

Preprint: experiments in animalsBiomarkers
Paper

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