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Chemicals targeting reactive oxygen species or a mitochondrial function-regulating enzyme

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Korea Institute of Toxicology and 6 more
  • Cells1

Outcomes

1

Senescence phenotypes

downin human cells1

1 study

  1. Chemicals targeting reactive oxygen species or a mitochondrial function-regulating enzyme decreases senescence phenotypes in human cells.

    “treating hPSC-derived senescent astrocytes with chemicals targeting reactive oxygen species or an enzyme that regulates mitochondrial function can reverse senescence phenotypes.”

    Cellssenescent astrocyteshPSC-derived astrocytes

    Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for Neurodegeneration

    Aging and disease12 Jun 2024

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