Apelin has been studied in 2 papers since 2018: 1 observational study in people, 1 in animals. The newest paper, Sep 10, 2026: “Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury”.
Studies of Apelin measured 7 outcomes; the most studied are cellular senescence (1 study), angiogenesis (1) and blood flow recovery (1).
Cellular senescence
downin mice1
Apelin decreases cellular senescence in mice.
“apelin facilitates neovascularization by improving endothelial function and mitigating ECs senescence via activation of APJ.”
Animalsin vitro and in vivo
Effects of apelin on age-associated neovascularization impairment in peripheral artery disease
Life sciences
Angiogenesis
upin mice1
Apelin increases angiogenesis in mice.
“apelin promotes neovascularization after ischemia.”
Animalsafter ischemia
Effects of apelin on age-associated neovascularization impairment in peripheral artery disease
Life sciences
Blood flow recovery
upin mice1
Apelin increases blood flow recovery in mice.
“In aged mice with HLI, apelin treatment markedly enhanced blood flow recovery.”
Animalshindlimb ischemia
Effects of apelin on age-associated neovascularization impairment in peripheral artery disease
Life sciences
Inflammation
downin mice1
Apelin inhibits inflammation in mice.
“this peptide considerably enhanced muscle function by triggering mitochondriogenesis, autophagy and anti-inflammatory pathways in myofibers”
Animalsrestoration of apelin signalingmyofiber
The exerkine apelin reverses age-associated sarcopenia
Nature medicine
Autophagy
upin mice1
Apelin activates autophagy in mice.
“this peptide considerably enhanced muscle function by triggering mitochondriogenesis, autophagy and anti-inflammatory pathways in myofibers”
Animalsrestoration of apelin signalingmyofiber
The exerkine apelin reverses age-associated sarcopenia
Nature medicine
Mitochondrial biogenesis (PGC-1α)
upin mice1
Apelin activates mitochondrial biogenesis (PGC-1α) in mice.
“this peptide considerably enhanced muscle function by triggering mitochondriogenesis, autophagy and anti-inflammatory pathways in myofibers”
Animalsrestoration of apelin signalingmyofiber
The exerkine apelin reverses age-associated sarcopenia
Nature medicine
Muscle function
upin mice1
Apelin improves muscle function in mice.
“this peptide considerably enhanced muscle function”
Animalsrestoration of apelin signalingskeletal muscle
The exerkine apelin reverses age-associated sarcopenia
Nature medicine
National Institute on AgingUS$299.5k
In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signaling protein, improved heart function.In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signaling protein, improved heart function.