Ischemia

Disease

3 papers

  • Humans1
  • Animals2

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bioRxiv

Metabolic pause protects donor livers and aids survival in rats

A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.

Preprint: experiments in ratsInterventions
Scientific Reports

A protein mutation curbs brain damage in mice with dementia

Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.Young and 18-month-old mice with an altered UCHL1 protein showed less white matter injury and better sensorimotor and cognitive performance in a dementia model.

Experiments in miceMechanisms
Stem Cell Research & Therapy

Young-donor cell packages improved limb repair in rats

In a rat experiment, cell-released packages from young donors had stronger tissue-repair effects than those from older donors after blood supply was restricted.In a rat experiment, cell-released packages from young donors had stronger tissue-repair effects than those from older donors after blood supply was restricted.

Experiments in ratsInterventions
Communications Biology

Three-protein combination eased chronic liver disease in rats

In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.

Experiments in ratsInterventions
Redox Biology

Ferroptosis inducers shorten lifespan in fruitflies

Erastin and RSL3 shortened survival dose-dependently, an effect rescued by ferrostatin-1, while altering iron and lipid profiles selectively in males.Erastin and RSL3 shortened survival dose-dependently, an effect rescued by ferrostatin-1, while altering iron and lipid profiles selectively in males.

Experiments in fliesFerroptosis