Anandamide
Anandamide has been studied in 2 papers since 2021: none in people yet, 2 in animals; 1 in the past year. The research so far is in animals. The newest paper, Feb 3, 2026: “Gut Microbiota-Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol-Induced Cognitive and Social Dysfunction via CB1R-DRD2-RAP1 Signaling Axis”.
- 3 independent labs in 2 countries
- Funders: Deutsche Forschungsgemeinschaft and 5 more
- Animals2
What did studies of Anandamide find?
3Studies of Anandamide measured 3 outcomes; the most studied are alcohol-induced cognitive and social dysfunction (1 study), ischemia-reperfusion injury (1) and AMPK signaling (1).
Alcohol-induced cognitive and social dysfunction
downin mice1
1 study
Alcohol-induced cognitive and social dysfunction
downin mice1
Anandamide decreases alcohol-induced cognitive and social dysfunction in mice.
“Treatment with UA-enriched Bacteroids sartorii and Parabacteroids distasonis, or their derived endocannabinoid-anandamide (AEA), also ameliorates AICSD.”
Animalsalcohol-induced cognitive and social dysfunction
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Ischemia-reperfusion injury
no changein mice1
1 study
Ischemia-reperfusion injury
no changein mice1
Anandamide has no effect on ischemia-reperfusion injury in mice.
“Supplementation of AEA to near-normal serum concentrations by repetitive intraperitoneal administration in CR mice, however, did not abrogate the protective effect of CR.”
Animalscaloric restrictionrepetitive intraperitoneal administrationnear-normal serum concentrationsmales
International journal of molecular sciences
AMPK signaling
upin mouse cells1
1 study
AMPK signaling
upin mouse cells1
Anandamide activates AMPK signaling in mouse cells.
“we analyzed effects of anandamide on AMP-activated kinase in cell culture and observed a significant activation of AMP-activated kinase.”
Cellsin cell culture
Molecular pain