15-pgdh inhibitors

1. 15-pgdh inhibitors have no effect on steady-state blood production in mice.

   “Notably, these effects occur without perturbing steady-state blood production”

   Animalssteady state

   15-PGDH inhibition enhances hematopoietic regeneration during aging

   Stem cells (Dayton, Ohio)·3 Jul 2025

1. 15-pgdh inhibitors decrease age-associated myeloid bias in mice.

   “PGDHi confers a competitive advantage in primary hematopoietic transplantation while mitigating age-associated myeloid bias in secondary transplants.”

   Animalssecondary hematopoietic transplantation

   15-PGDH inhibition enhances hematopoietic regeneration during aging

   Stem cells (Dayton, Ohio)·3 Jul 2025

1. 15-pgdh inhibitors improve competitive hematopoietic transplantation capacity in mice.

   “PGDHi confers a competitive advantage in primary hematopoietic transplantation”

   Animalsprimary hematopoietic transplantation

   15-PGDH inhibition enhances hematopoietic regeneration during aging

   Stem cells (Dayton, Ohio)·3 Jul 2025

1. 15-pgdh inhibitors improve short-term hematopoietic recovery in mice.

   “PGDHi-treated BM enhances short-term hematopoietic recovery following transplantation, leading to improved peripheral blood output and accelerated multilineage reconstitution”

   Animalsfollowing transplantation of PGDHi-treated bone marrowbone marrow

   15-PGDH inhibition enhances hematopoietic regeneration during aging

   Stem cells (Dayton, Ohio)·3 Jul 2025

1. 15-pgdh inhibitors increase phenotypic hematopoietic stem and progenitor cell frequency and number in mice.

   “prolonged PGDH inhibition (PGDHi) significantly increases the frequency and number of phenotypic hematopoietic stem and progenitor cells across multiple compartments”

   Animalsmultiple compartmentsprolonged

   15-PGDH inhibition enhances hematopoietic regeneration during aging

   Stem cells (Dayton, Ohio)·3 Jul 2025

More on Phenotypic hematopoietic stem and progenitor cell frequency and number