Brain dynamic connectivity
upin humans1
Oxytocin increases brain dynamic connectivity in humans.
“OT significantly altered temporal properties of brain states, including increased frequency, in-degree, and out-degree in multiple CAPs, indicating enhanced network flexibility and switching.”
Human trialsingle intranasal doseintranasalbrain
Molecular psychiatry24 Mar 2026
Functional connectivity
upin humans1
Oxytocin increases functional connectivity in humans.
“OT enhanced functional connectivity within the left TPJ and between the left and right TPJ in both age groups.”
Human trialintranasaltemporoparietal junction
Behavioural brain research6 Dec 2025
Fractional amplitude of low-frequency fluctuations
upin humans1
Oxytocin increases fractional amplitude of low-frequency fluctuations in humans.
“OT also elevated the fractional amplitude of low-frequency fluctuations (fALFF) in the same region, particularly in YA.”
Human trialintranasalleft temporoparietal junction
Behavioural brain research6 Dec 2025
Cellular senescence
downin reviews1
Oxytocin decreases cellular senescence.
“oxytocin signaling, which supports parental caregiving and physiological investments that slow senescence”
Review
Neuroscience and biobehavioral reviews6 Nov 2025
Longevity
upin reviews1
Oxytocin increases longevity.
“oxytocin signaling, which supports parental caregiving and physiological investments that slow senescence, thereby increasing longevity”
Review
Neuroscience and biobehavioral reviews6 Nov 2025
Cognitive function
upin humans1
Oxytocin is associated with cognitive function in humans.
“Importantly, only in the elderly OT and combined young subgroups did time spent in these states significantly correlate with cognitive performance on the Digit Symbol Substitution Test”
Human trialsingle intranasal dose of OTintranasalbrain
Molecular psychiatry24 Mar 2026
National Heart, Lung, and Blood InstituteUS$992.2kNational Institute of Neurological Disorders and StrokeUS$50k
Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling.Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling.