TCFEB

1. Dexmedetomidine activates TCFEB in mice.

   “promoted TFEB nuclear translocation in microglia, correlating with enhanced lysosomal gene transcription”

   Animalsin aged micehippocampus

   Dexmedetomidine mitigates postoperative delirium in aged mice via TFEB-linked restoration of microglial lysosomal function and attenuated neuroinflammation

   Experimental neurology·30 Apr 2026

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1. CXM102 activates TCFEB in mouse cells.

   “CXM102 promoted transcription factor EB (TFEB) nuclear translocation”

   Cells

   Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice

   Bone research·21 Aug 2024

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1. Caloric restriction increases TCFEB in mice.

   “nuclear TFEB levels are augmented in the livers of mice subjected to dietary restriction”

   Animalsliver

   The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

   Nature communications·1 Jan 2013

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