CXM102

1 paper5 findings

1 lab in 1 country

Funder: Science and Technology Department of Guangxi Zhuang Autonomous

Animals1

Outcomes

5

Autophagy

upin mouse cells1

1 study

CXM102 activates autophagy in mouse cells.
“CXM102 that could induce autophagy in aged BMSCs”
Cells
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone research21 Aug 2024

More on Autophagy

TCFEB

upin mouse cells1

1 study

CXM102 activates TCFEB in mouse cells.
“CXM102 promoted transcription factor EB (TFEB) nuclear translocation”
Cells
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone research21 Aug 2024

Organ fibrosis

downin mice1

1 study

CXM102 decreases organ fibrosis in mice.
“reduced organ fibrosis”
Animalsmales
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone research21 Aug 2024

Age-related bone loss

downin mice1

1 study

CXM102 decreases age-related bone loss in mice.
“delayed bone loss in middle-age male mice”
Animalsmales
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone research21 Aug 2024

Lifespan

upin mice1

1 study

CXM102 extends lifespan in mice.
“leading to a prolonger lifespan in male mice”
Animalsmales
Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice
Bone research21 Aug 2024

Latest

Bone Research21 Aug

Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice

Experiments in miceBones and joints