hlh-30

Gene5 papers1 findingNCBI Gene 177157Taxon 6239

Model organisms5

Effects

1

Lifespan

is required forin worms1

1 study

hlh-30 is required for lifespan in worms.
“These benefits require hlh-30, the ortholog of mammalian transcription factor EB (TFEB).”
Reviewduring heat shock-induced hormesis
Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways · bioRxiv · 3 Sep 2026 · Preprint

Latest

5

Journal of EthnopharmacologyModel organisms23 Sep

Parishin B, a phenolic constituent of Gastrodia elata Blume, extends lifespan and improves stress resistance in Caenorhabditis elegans

The Journal of Nutritional BiochemistryModel organisms13 Sep

Silibinin Ameliorated Lipid Accumulation Through Insulin/IGF-1 signaling Pathway in HGI C. elegans

bioRxivModel organismsPreprint3 Sep

Hormetic heat shock activates HLH-30/TFEB independently of canonical nutrient-sensing pathways

Mechanisms of Ageing and DevelopmentModel organisms21 Aug

Puerarin extends lifespan and enhances the resistance to oxidative stress through AMPK/TFEB mediated autophagy in Caenorhabditis elegans

bioRxivModel organismsPreprint21 Aug

TBC-2, a Rab GTPase activating protein, regulates the localization of the HLH-30/TFEB and PQM-1 transcription factors in the C. elegans intestine

Gut and microbiome