Postoperative delirium
Disease3 papers3 findings
- Humans1
- In silico1
Upstream
1RGL2
no changein humans1
1 study
RGL2
no changein humans1
RGL2 has no effect on postoperative delirium in humans.
Humansdelirium genome-wide association study proxy
Integrative transcriptomics identifies shared aging-associated inhibitory-neuron states and prioritizes RGL2 across postoperative delirium and Alzheimer's disease · Journal of molecular neuroscience : MN · 29 Aug 2026
Associations
2Autonomic adaptability
upin humans1
1 study
Autonomic adaptability
upin humans1
Autonomic adaptability predicts postoperative delirium in humans.
Reviewolder surgical patients
The perioperative brain-heart-immune axis: autonomic resilience, multimodal monitoring and postoperative delirium · Frontiers in medicine · 14 Aug 2026
mFI-5
upin humans1OR 3.07
1 study
mFI-5
upin humans1OR 3.07
mFI-5 raises the risk of postoperative delirium in humans (adjusted OR 3.07 (95% CI 1.08-8.60, p = 0.035)).
Humansin patients undergoing surgery for OSCC, adjusted for age ≥65 years and sexn = 127
Modified 5-Item Frailty Index Is Associated with Postoperative Delirium but Not Survival in Patients Undergoing Surgery for Oral Squamous Cell Carcinoma · Diagnostics (Basel, Switzerland) · 13 Aug 2026
Trial sponsors
Nanjing University School of Medicine
1 trialPhase 3260 people
Universitaire Ziekenhuizen KU Leuven
1 trial256 people
Funding
National Institute on AgingUS$4.8m10 grants since 2019
National Institute on AgingIndiana University IndianapolisUS$136.4k2022–2027
Postoperative Delirium- Unmasking of Pre-existing Deficits, or De Novo Injury to the Brain
National Institute on AgingStanford UniversityUS$215.4k2026–2031
Bidirectional relationships between plasma tau phosphorylation markers and postoperative delirium
National Institute on AgingDuke UniversityUS$444.1k2026–2028
Defining the role of lipocalin-2 in postoperative delirium
National Institute on AgingDuke UniversityUS$647.8k2026–2031
National Institute on AgingWeill Medical Coll of Cornell UnivUS$172.3k2026–2031
Neuroinflammation, Perineural Nets, and Postoperative Delirium
National Institute on AgingMassachusetts General HospitalUS$791.6k2024–2029
National Institute on AgingStanford UniversityUS$379.7k2021–2027
National Institute on AgingStanford UniversityUS$746k2025–2030
Impact of hypertension and aging on postoperative delirium
National Institute on AgingDuke UniversityUS$700.4k2025–2030
Postoperative Delirium and Alzheimer's Disease Related Dementias
National Institute on AgingUniversity of Texas Hlth Sci Ctr HoustonUS$591.3k2019–2027