PIT1
9 papers2 findings
- 1 lab in 1 country
- Funders: National Institute on Aging and 1 more
- Animals7
Effects
2IRS-1-associated PI3K activity
downin mice1
1 study
IRS-1-associated PI3K activity
downin mice1
PIT1 decreases IRS-1-associated PI3K activity in mice.
“Our data show that the PI3K activity associated with IRS-1, the docking of IRS-1 to InR beta and the docking of p85 alpha to IRS-1 are attenuated in the aged Snell dwarf.”
AnimalsPit1(dw)/Pit1(dw)liver
Mechanisms of ageing and development1 May 2002
Insulin/IGF-1 signalling
downin mice1
1 study
Insulin/IGF-1 signalling
downin mice1
PIT1 inhibits insulin/IGF-1 signalling in mice.
“In this study we present data suggesting that the InR beta-IRS-1-PI3K pathway is attenuated in the Snell dwarf mouse liver.”
AnimalsPit1(dw)/Pit1(dw)liver
Mechanisms of ageing and development1 May 2002
Latest
Journal of Molecular Endocrinology
Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice
Experiments in miceMechanisms
The Journals of Gerontology, Series A
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice
Experiments in miceMechanisms
The Journals of Gerontology, Series A
Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span
Experiments in miceMechanisms
Mechanisms of Ageing and Development
Higher levels of heat shock proteins in longer-lived mammals and birds
Experiments in miceHeat shock response and chaperones
Mechanisms of Ageing and Development
Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse
Experiments in micePI3K–AKT signalling