IRS-1-associated PI3K activity

1 paper1 finding

Animals1

Upstream

1

PIT1

downin mice1

1 study

PIT1 decreases IRS-1-associated PI3K activity in mice.
“Our data show that the PI3K activity associated with IRS-1, the docking of IRS-1 to InR beta and the docking of p85 alpha to IRS-1 are attenuated in the aged Snell dwarf.”
AnimalsPit1(dw)/Pit1(dw)liver
Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse
Mechanisms of ageing and development1 May 2002

Latest

Mechanisms of Ageing and Development1 May

Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

Experiments in micePI3K–AKT signalling