DBC1

1. DBC1 improves muscle regeneration in mice.

   “Muscle regeneration was hampered in mice with CTX-induced muscle injury by DBC1 knockdown”

   AnimalsCTX-induced muscle injuryskeletal muscle

   DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting

   Journal of cachexia, sarcopenia and muscle·Dec 7, 2023

1. DBC1 decreases muscular atrophy in mice.

   “overexpress DBC1-attenuated atrophic phenotypes in these mice”

   Animalsin age-related or limb immobilization-induced atrophic mouse musclesskeletal muscle

   DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting

   Journal of cachexia, sarcopenia and muscle·Dec 7, 2023

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1. DBC1 decreases muscle mass in mice (-14.3% (P = 0.007)).

   “a 14.3% reduction in muscle mass (P = 0.007) and significantly smaller myofibre cross-sectional areas (P < 0.0001)”

   Animalsskeletal musclemales

   DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting

   Journal of cachexia, sarcopenia and muscle·Dec 7, 2023

1. DBC1 impairs grip strength in mice (-28% (P = 0.023)).

   “DBC1 knockdown in skeletal muscle of young mice led to signatures of muscle atrophy, including a 28% reduction in muscle grip force (P = 0.023)”

   Animalsskeletal musclemales

   DBC1 maintains skeletal muscle integrity by enhancing myogenesis and preventing myofibre wasting

   Journal of cachexia, sarcopenia and muscle·Dec 7, 2023

1. Intervertebral disc degeneration is associated with DBC1.

   “DBC1 expression is significantly upregulated in IVDD.”

   Animalsnucleus pulposus

   DBC1 promotes intervertebral disc degeneration by activating NF-κB pathway and inhibiting SIRT1 activity

   Life sciences·May 6, 2025

More on Intervertebral disc degeneration