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CCNDBP1

Gene

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Natural Science Foundation of Zhejiang Province
  • Animals1

Effects

3

SIRT1

downin rat cells1

1 study

  1. CCNDBP1 inhibits SIRT1 in rat cells.

    “DBC1 activates the NF-κB signaling pathway while suppressing SIRT1 expression in nucleus pulposus cells”

    Cellsnucleus pulposus

    DBC1 promotes intervertebral disc degeneration by activating NF-κB pathway and inhibiting SIRT1 activity

    Life sciencesMay 6, 2025

More on SIRT1

Apoptosis

upin rat cells1

1 study

  1. CCNDBP1 induces apoptosis in rat cells.

    “DBC1 appears to contribute to IVDD by promoting apoptosis, senescence, and ECM degradation in nucleus pulposus cells.”

    Cellsnucleus pulposus

    DBC1 promotes intervertebral disc degeneration by activating NF-κB pathway and inhibiting SIRT1 activity

    Life sciencesMay 6, 2025

More on Apoptosis

Cellular senescence

upin rat cells1

1 study

  1. CCNDBP1 induces cellular senescence in rat cells.

    “DBC1 appears to contribute to IVDD by promoting apoptosis, senescence, and ECM degradation in nucleus pulposus cells.”

    Cellsnucleus pulposus

    DBC1 promotes intervertebral disc degeneration by activating NF-κB pathway and inhibiting SIRT1 activity

    Life sciencesMay 6, 2025

More on Cellular senescence

Associations

1

Intervertebral disc degeneration

upin rats1

1 study

  1. CCNDBP1 raises the risk of intervertebral disc degeneration in rats.

    “DBC1 appears to contribute to IVDD by promoting apoptosis, senescence, and ECM degradation in nucleus pulposus cells.”

    Animalsnucleus pulposus

    DBC1 promotes intervertebral disc degeneration by activating NF-κB pathway and inhibiting SIRT1 activity

    Life sciencesMay 6, 2025

More on Intervertebral disc degeneration

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