Trisomy 21
3 papers5 findings
- Humans1
- Animals1
Effects
1B cells
downin humans1
1 study
B cells
downin humans1
Trisomy 21 decreases B cells in humans.
“T21 causes progressive shifts in B cell subsets together with accelerated age-dependent B cell loss linked to hyperactive interferon and JAK/STAT signaling.”
Humans
bioRxiv : the preprint server for biology4 Aug 2026Preprint
Associations
4Senescence-associated secretory phenotype (SASP)
upin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
upin human cells1
Trisomy 21 is associated with senescence-associated secretory phenotype (SASP) in human cells.
“These results were confirmed by real-time quantitative PCR showing an increase of the SEN marker CDKN2B and SASP markers IL-6 and CXCL8.”
Cellslung
Elevated Senescence Markers in Developing Trisomy 21 Human Lungs
American journal of respiratory cell and molecular biology28 Feb 2025
Oxidative stress and ROS signalling
upin human cells1
1 study
Oxidative stress and ROS signalling
upin human cells1
Trisomy 21 is associated with oxidative stress and ROS signalling in human cells.
“Only T21 fibroblasts displayed a significant increase in reactive oxygen species levels, as indicated by MitoSOX and CellROX.”
Cellslung
Elevated Senescence Markers in Developing Trisomy 21 Human Lungs
American journal of respiratory cell and molecular biology28 Feb 2025
DNA damage response
upin human cells1
1 study
DNA damage response
upin human cells1
Trisomy 21 is associated with DNA damage response in human cells.
“Telomerase-associated foci staining showed DNA damage primarily within T21 and T18 lungs.”
Cellslung
Elevated Senescence Markers in Developing Trisomy 21 Human Lungs
American journal of respiratory cell and molecular biology28 Feb 2025
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Trisomy 21 is associated with cellular senescence in human cells.
“Isolated fibroblasts demonstrated a strong association between T21 and several SEN markers.”
Cellsin prenatal lung tissue and isolated fibroblastslung
Elevated Senescence Markers in Developing Trisomy 21 Human Lungs
American journal of respiratory cell and molecular biology28 Feb 2025
Trial sponsors
Children's Mercy Hospital Kansas City
1 trialPhase 46 people
Funding
3 grants since 2023National Heart, Lung, and Blood InstituteUS$1.2mNational Institute on AgingUS$2.6mNational Institute of Child Health and Human DevelopmentUS$2.2m
Cellular Senescence in Trisomy 21 lung disease
National Heart, Lung, and Blood InstituteLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterUS$610.4k2024–2028
Sleep Spindle Dynamics as a Clinical Biomarker of Aging, Alzheimer's Disease, and Trisomy 21
National Institute on AgingBrigham and Women's HospitalUS$2.6m2023–2026
National Institute of Child Health and Human DevelopmentVirginia Commonwealth UniversityUS$2.2m2023–2026