Neurodegenerative disorders

Latest

HumansPreprintBrain aging5 h

Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains

Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.

bioRxiv : the preprint server for biology · Bidhan V et al.

Paper

Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants

Model organismsPreprintbioRxiv : the preprint server for biology5 h

Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease

Model organismsGeneYesterday

Ferroptosis-Driven Inflammaging in Age-Associated Degenerative Disorders: Molecular Mechanisms and Therapeutic Potential of Natural Products

ReviewAgeing research reviewsYesterday

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

ReviewMedCommYesterday

Cellular and systemic modifiers of alpha-synuclein proteostasis

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1 Oct

Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1 Oct

AnimalsPeer-reviewedMitochondria1 Oct

Icariin improves cognition and reduces neuroinflammation by promoting mitophagy in mice

The flavonoid engages PINK1 to curb microglial pyroptosis and mitochondrial stress in models of Alzheimer's disease.

Chinese journal of natural medicines · Fan L et al.

Paper

Redox-Mitochondrial Crosstalk in Neurotoxicity: Regulated Cell Death Pathways and Neuroprotective Strategies

ReviewAgeing research reviews1 Oct

Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms

ReviewFrontiers in neuroscience1 Oct