GIPR
Gene4 papers3 findingsHGNC 4271NCBI Gene 2696Taxon 9606
- Human trial2
- Humans2
Effects
1Barrett's oesophagus
no changein silico1OR 1
1 study
Barrett's oesophagus
no changein silico1OR 1
GIPR has no effect on Barrett's oesophagus in silico (OR 1.00, 95% CI 0.42-2.37).
“estimates were near the null for both receptors (GLP-1R 0.96, 0.47-1.96; GIPR 1.00, 0.42-2.37)”
In silico
Genetic Assessment of Oesophageal Safety of GLP-1 and GIP Receptor Perturbation: A Drug-Target Mendelian Randomisation Study · Biomedicines · 24 Aug 2026
Associations
2Spine-and-hip fractures
downin humans1OR 0.68
1 study
Spine-and-hip fractures
downin humans1OR 0.68
GIPR lowers the risk of spine-and-hip fractures in humans (OR 0.68, 95% CI 0.49-0.94).
Humansscaled to lower BMI
Genetically proxied GIP pathway links to lower fracture risk · Diabetes, obesity & metabolism · 29 Sep 2026
Major osteoporotic fractures
downin humans1OR 0.8
1 study
Major osteoporotic fractures
downin humans1OR 0.8
GIPR lowers the risk of major osteoporotic fractures in humans (OR 0.80, 95% CI 0.66-0.98).
Humansscaled to lower BMI
Genetically proxied GIP pathway links to lower fracture risk · Diabetes, obesity & metabolism · 29 Sep 2026
Latest
4Retatrutide reduces weight and pain in adults with obesity
Mean body weight fell up to 25.0% with retatrutide versus 3.9% on placebo over 80 weeks in adults with obesity.Mean body weight fell up to 25.0% with retatrutide versus 3.9% on placebo over 80 weeks in adults with obesity.
Genetically proxied GIP pathway links to lower fracture risk
Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip…Scaled to lower BMI, genetically proxied GIP-GIPR perturbation tracked with lower odds of major osteoporotic fractures (OR 0.80) and spine-and-hip fractures (OR 0.68).