Lipofuscinosis

2 papers

Animals2

Latest

5 in 12 months

Neuron11 Aug

Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction

Experiments in miceTelomerase and telomere maintenance

Immunity4 Aug

Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

Experiments in miceAutophagy

Research Square23 Feb

Deficient de-S-acylation in aging and CLN1 contributes to lyso-mitochondrial dysfunction, lipid dyshomeostasis, and resultant lipofuscin biogenesis

Preprint: experiments in miceAutophagy

bioRxiv15 Jan

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

Preprint: experiments in miceTelomerase and telomere maintenance

Biochemistry Biokhimiia27 Dec

Progeroid Syndrome with Signs of Autophagy Dysfunction in the Naked Mole Rat (Heterocephalus glaber)

Experiments in naked mole-ratsAutophagy

Neuropathology and Applied Neurobiology24 Sep

Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin

Study in peopleMechanisms

International Journal of Molecular Sciences14 Aug

Phenotype Differences Between ATP13A2 Heterozygous and Knockout Mice Across Aging

Experiments in animalsMechanisms

Science Translational Medicine14 May

An AAV variant selected through NHP screens robustly transduces the brain and drives secreted protein expression in NHPs and mice

Experiments in animalsInterventions

Research Square1 Apr

Molecular elucidation of brain lipofuscin in aging and Neuronal Ceroid Lipofuscinosis

Preprint: experiments in animalsMechanisms

Frontiers in Cell and Developmental Biology23 Jan

The Batten disease gene Cln3 is required for the activation of intestinal stem cell during regeneration via JAK/STAT signaling in Drosophila

Experiments in model organismsMechanisms