Aav soluble DLK1

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Oligodendrocyte lineage progression

downin mice1

1 study
  1. Aav soluble DLK1 inhibits oligodendrocyte lineage progression in mice.

    “AAV delivery of sDLK1 in vivo caused hypomyelination and blocked oligodendrocyte lineage progression”

    AnimalsAAV deliveryoligodendrocyte

    Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

    bioRxiv (Cold Spring Harbor Laboratory)15 Jan 2026Preprint

Hypomyelination

upin mice1

1 study
  1. Aav soluble DLK1 induces hypomyelination in mice.

    “AAV delivery of sDLK1 in vivo caused hypomyelination and blocked oligodendrocyte lineage progression”

    AnimalsAAV delivery

    Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

    bioRxiv (Cold Spring Harbor Laboratory)15 Jan 2026Preprint

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