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Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

By Leon Tejwani, Catherine M Heffner, Christopher D. Balak, Show 18 more authorsGilbert Di Paolo
Experiments in miceMechanisms
Paper

The paper

Leon Tejwani, Catherine M Heffner, Christopher D. Balak, Show 18 more authorsGilbert Di Paolo

Denali Therapeutics (United States)

Immunity, 3 Aug 2026

doi.org/10.1016/j.immuni.2026.07.009PubMed 42546695

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