Frontotemporal dementia
Disease2 papersMeSH D057180
- Humans1
Latest
5Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
bioRxiv : the preprint server for biology · Bidhan V et al.
Speech clocks reflect dementia phenotypes and biological aging markers
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Science advances · Hernandez H et al.
Early social isolation accelerates TDP-43 neurodegeneration and shortens lifespan in fruit flies
Young flies housed alone showed faster retrovirus activation and more aggressive protein spread from glia to neurons.
bioRxiv · Murthygowda S et al.
Lysosomal dysfunction in neurodegenerative disease
ReviewNature reviews. Neurology