3 papers1 finding
Psychological stress
upin humans1
Psychological stress predicts diseases of aging in humans.
“Accumulation of life stressors predicts accelerated development and progression of diseases of aging.”
Review
Social and personality psychology compass5 Nov 2012
National Institute on AgingUS$7.2m
Molecular mechanisms of calcification: roles and opportunities in diseases of aging
National Institute on AgingMedical College of WisconsinUS$2.6m2023–2028
Metabolomic profile of chronic distress in relation to diseases of aging across diverse populations
National Institute on AgingUniversity of Massachusetts AmherstUS$769k2017–2027
MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)
National Institute on AgingMassachusetts General HospitalUS$268.7k2023–2027
Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.
Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.
In an observational study of 58 people with HIV and 95 uninfected adults, HIV was linked to poorer balance across all tested tasks.In an observational study of 58 people with HIV and 95 uninfected adults, HIV was linked to poorer balance across all tested tasks.
Brain recordings in awake mice revealed higher excitation, altered electrical rhythms, and less distinct smell signals in the olfactory bulb of older animals.Brain recordings in awake mice revealed higher excitation, altered electrical rhythms, and less distinct smell signals in the olfactory bulb of older animals.
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.