Dependence

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Cell Metabolism

Fat-derived protein helped protect muscle in study models

Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.Research in models of aging, disuse and cancer-related wasting identified a fat-derived protein as a key mediator of protection from a metabolic supplement.

Experiments in animalsMuscle
Brain, Behavior, and Immunity

Aged mice changed behaviour after sepsis without broad inflammation

Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behaviour despite comparable…Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behaviour despite comparable illness severity.

Experiments in miceInflammation
arXiv

Predicted gene responses vary more with age in a computer model

A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.A computational analysis of single-cell gene activity data predicted increasingly different responses to disrupting the same gene at older ages.

Preprint: computational studyMechanisms
arXiv

Brain activity changes differ from age-group patterns

A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.A longitudinal observational analysis of the Dallas Lifespan Brain Study found substantial differences in early and middle adulthood that diminished later in life.

Preprint: cohort study in peoplePopulations