Cartilage destruction

1 paper

Animals1

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4 in 12 months

Ageing Research Reviews11 Jul

Mitochondrial-ER stress crosstalk in osteoarthritis: From ageing-associated chondrocyte dysfunction to emerging therapeutics

ReviewER unfolded protein response

International Immunopharmacology9 May

FBXO7 protects against osteoarthritis by promoting IL-6 ubiquitination and inhibiting JAK1/STAT3 signaling

Experiments in miceIL-6 signalling

Annals of Medicine6 Mar

Critical role of Sirtuin 6 (SIRT6) in osteoarthritis chondrocytes: the interaction among various biological processes

ReviewSirtuin signalling

Cell Biology and Toxicology1 Feb

Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence

Experiments in miceCellular senescence

Journal of Advanced Research13 Oct

MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis

Experiments in miceOsteoarthritis

Journal of Orthopaedic Translation23 Jul

Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway

Experiments in miceBones and joints

Cellular Signalling1 May

SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy

Experiments in miceCellular senescence

Journal of Inflammation Research17 Feb

The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies

ReviewBones and joints

Advanced Science5 Jan

Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis

Experiments in miceOsteoarthritis

Journal of Nanobiotechnology26 Oct

Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration

Experiments in animalsInterventions