Dihydroartemisinin

1. Dihydroartemisinin increases extracellular matrix synthesis in mouse cells.

   “Similarly, in vitro experiments confirmed that DHA promoted the synthesis of ECM in blood-stimulated chondrocytes with a dose-dependent manner.”

   Cellsin blood-stimulated chondrocytescartilage1, 5 or 10 μM24 h

   Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway

   Journal of orthopaedic translation·24 Apr 2025

1. Dihydroartemisinin decreases oxidative stress and ROS signalling in mouse cells.

   “DHA also effectively suppressed blood-induced chondrocyte senescence and ROS accumulation.”

   Cellsin blood-stimulated chondrocytescartilage1, 5 or 10 μM24 h

   Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway

   Journal of orthopaedic translation·24 Apr 2025

More on Oxidative stress and ROS signalling

1. Dihydroartemisinin decreases cellular senescence in mouse cells.

   “DHA also effectively suppressed blood-induced chondrocyte senescence and ROS accumulation.”

   Cellsin blood-stimulated chondrocytescartilage1, 5 or 10 μM24 h

   Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway

   Journal of orthopaedic translation·24 Apr 2025

More on Cellular senescence

1. Dihydroartemisinin decreases cartilage degeneration in mice.

   “DHA remarkably ameliorated the cartilage degeneration in both two hemarthrosis models.”

   Animalsin two hemarthrosis modelscartilage10 or 20 mg/kg/day4 weeks

   Dihydroartemisinin ameliorates hemarthrosis-induced cartilage degeneration by suppressing chondrocyte senescence via activation of Keap1-Nrf2 signaling pathway

   Journal of orthopaedic translation·24 Apr 2025