White matter lesions

1. Cardiorespiratory fitness decreases white matter lesions in humans.

   “higher CRF was related to less PVWMLs and DWMLs”

   Humansn = 118

   Cognitive Aging and Cerebrovascular Health: Role of White Matter Lesions and Cardiorespiratory Fitness

   Preprint·Dec 31, 2023

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1. White matter lesions decrease gait velocity in humans.

   “WMLs in the sublobar (basal ganglia/internal capsule) and limbic areas and lacunar infarcts in the frontal lobe and thalamus were related to a lower velocity.”

   Humanscerebral small vessel diseasesublobar and limbic areasn = 431

   Gait in elderly with cerebral small vessel disease

   Stroke·Jun 24, 2010

1. White matter lesions impair gait in humans.

   “WMLs and lacunar infarcts were both independently associated with most gait parameters”

   Humanscerebral small vessel diseasen = 431

   Gait in elderly with cerebral small vessel disease

   Stroke·Jun 24, 2010

1. Intraindividual cognitive variability has no effect on white matter lesions in humans (all p's > .05).

   “IIV showed no significant association with WMLs, neither within nor across the domains examined (all p’s>.05).”

   Humansolder adults without dementian = 70

   ASSOCIATIONS OF MEAN COGNITIVE PERFORMANCE AND INTRAINDIVIDUAL VARIABILITY WITH WHITE MATTER LESIONS

   GSA 2024 abstract·Dec 31, 2024

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1. Multilingualism is associated with white matter lesions in humans.

   “and increased white matter lesions, both at baseline and follow-up examinations.”

   Humanscompared to monolingualswhite matter2 yearsn = 397

   Use of Multiple Languages Provides Cognitive Reserve Amidst Age-Related White Matter Changes

   The journals of gerontology. Series B, Psychological sciences and social sciences·Apr 8, 2025

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1. Global cognition is associated with white matter lesions in humans.

   “and in global cognition (B=-.065, p=.003) lower MP was associated with more WMLs.”

   Humansolder adults without dementian = 70

   ASSOCIATIONS OF MEAN COGNITIVE PERFORMANCE AND INTRAINDIVIDUAL VARIABILITY WITH WHITE MATTER LESIONS

   GSA 2024 abstract·Dec 31, 2024

1. Executive function is associated with white matter lesions in humans.

   “executive function (B=-.039, p=.018), and in global cognition (B=-.065, p=.003) lower MP was associated with more WMLs.”

   Humansolder adults without dementian = 70

   ASSOCIATIONS OF MEAN COGNITIVE PERFORMANCE AND INTRAINDIVIDUAL VARIABILITY WITH WHITE MATTER LESIONS

   GSA 2024 abstract·Dec 31, 2024

1. Cognitive function is associated with white matter lesions in humans.

   “In the domains of memory (B=-.035, p=.025), executive function (B=-.039, p=.018), and in global cognition (B=-.065, p=.003) lower MP was associated with more WMLs.”

   Humansolder adults without dementian = 70

   ASSOCIATIONS OF MEAN COGNITIVE PERFORMANCE AND INTRAINDIVIDUAL VARIABILITY WITH WHITE MATTER LESIONS

   GSA 2024 abstract·Dec 31, 2024

1. Arteriosclerosis predicts white matter lesions in humans (by nearly a decade).

   “a precipitous decline in cerebral arterial elasticity (measured with diffuse optical imaging of the cerebral arterial pulse; pulse-DOT) temporally precedes an acceleration in the development of white matter lesions by nearly a decade”

   Humansn = 203

   Neurovascular Mechanisms of Cognitive Aging: Sex-Related Differences in the Average Progression of Arteriosclerosis, White Matter Atrophy, and Cognitive Decline

   bioRxiv : the preprint server for biology·Mar 21, 2024Preprint

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1. White matter lesions are associated with dopamine D1 receptor availability in humans.

   “Further analyses revealed an association between distance to lesions and extent of D1DR losses in the caudate.”

   Humansstriatumn = 119

   Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum

   Aging brain·Aug 16, 2023

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1. White matter lesions are associated with total enlarged perivascular spaces in humans (P = 0.005).

   “Total enlarged perivascular spaces were associated with increasing age (P = 0.01), deep white matter lesions (P = 0.005), and previous stroke (P = 0.006).”

   Humansbrainn = 298

   Enlarged perivascular spaces and cerebral small vessel disease

   International journal of stroke : official journal of the International Stroke Society·May 22, 2013

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