White matter hyperintensities
Disease1 paper
- Humans1
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11Education links to better cognition independent of brain pathology
Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after…Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after adjusting for multimodal brain pathology.
Plasma CXCL10 links to higher stroke risk in older adults
Each 1-standard deviation higher CXCL10 was linked to 20% greater stroke risk over a median follow-up of 14 years.Each 1-standard deviation higher CXCL10 was linked to 20% greater stroke risk over a median follow-up of 14 years.
Brain small vessel disease links to stroke and mortality risk
Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.
Brain MRI predicts conversion to mild cognitive impairment
Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.
Mind the brain age: How segmentation and template selection reshape structural connectomes
GLP-1 receptor agonists link to lower stroke and Alzheimer risk
A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced…A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced risk of stroke and Alzheimer disease.
DASH diet across adulthood links to better late-life brain health
In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory.In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory.
White matter damage is linked to greater cortical thinning in men
In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical…In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men.