Fazekas score

Biomarker

6 papers4 findings

  • Humans5
  • In silico1

Effects

3

Left caudate volume

mediatesin humans1

1 study
  1. Fazekas score mediates left caudate volume in humans (indirect effect = 1.761, P=0.035, 23.0% of total effect).

    “Fazekas scores were found to partially mediate the relationship between the p-Tau 181 levels and left caudate volumes (indirect effect =1.761, P=0.035)”

    Humanscognitively normalbrain

    Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging

    Quantitative imaging in medicine and surgery23 Jan 2026

More on Left caudate volume

Learning and memory

downin humans1

1 study
  1. Fazekas score impairs learning and memory in humans (β = 0.0313, p = 0.195).

    “In MCI, higher Fazekas-Total was associated with poorer learning and memory (p = 0.195, β = 0.0313)”

    Humansmild cognitive impairment participants

    Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes

    Aging17 Nov 2025

Attention

downin humans1

1 study
  1. Fazekas score impairs attention in humans (β = 0.422, p = 0.015).

    “In CN participants, higher Fazekas-Total was associated with impaired attention (p = 0.015, β = 0.422)”

    Humanscognitively normal participants

    Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes

    Aging17 Nov 2025

Associations

1

Phosphorylated tau 181

upin humans1

1 study
  1. Phosphorylated tau 181 is associated with Fazekas score in humans (r=0.165, P=0.015).

    “the plasma p-Tau 181 levels were found to be positively correlated with the Fazekas scores (r=0.165, P=0.015)”

    Humanscognitively normalbrainn = 218

    Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging

    Quantitative imaging in medicine and surgery23 Jan 2026

More on Phosphorylated tau 181

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