Cardiorespiratory fitness

4 papers9 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 4 countries

Funders: National Institute on Aging and others

Humans4

Outcomes

Metabolic syndrome score

downin humans1

1 study

Cardiorespiratory fitness decreases metabolic syndrome score in humans.
“CR-fitness was inversely associated with an overall metabolic syndrome score”
Humansn = 1,293
Cardiorespiratory fitness and the metabolic syndrome: Roles of inflammation and abdominal obesity
PloS one28 Mar 2018

Associations

Motor skills

upin humans1

1 study

Cardiorespiratory fitness is associated with motor skills in humans (B = 0.012, p = 0.018).
“motor skills B = 0.012, p = 0.018) after adjustment for age, sex, education years”
Humansn = 877
Fitness and cognition in the elderly: The Austrian Stroke Prevention Study
Neurology6 Jan 2016

Executive function

upin humans1

1 study

Cardiorespiratory fitness is associated with executive function in humans (B = 0.009, p = 0.003).
“executive function B = 0.009, p = 0.003; motor skills B = 0.012, p = 0.018”
Humansn = 877
Fitness and cognition in the elderly: The Austrian Stroke Prevention Study
Neurology6 Jan 2016

Memory

upin humans1

1 study

Cardiorespiratory fitness is associated with memory in humans (B = 0.026, p = 0.000).
“memory B = 0.026, p = 0.000; executive function B = 0.009, p = 0.003; motor skills B = 0.012, p = 0.018”
Humansn = 877
Fitness and cognition in the elderly: The Austrian Stroke Prevention Study
Neurology6 Jan 2016

Global cognitive function

upin humans1

1 study

Cardiorespiratory fitness is associated with global cognitive function in humans (B = 0.024; p = 0.000).
“Higher V̇o2max was associated with better global (B = 0.024; p = 0.000) and domain-specific cognitive function”
Humansn = 877
Fitness and cognition in the elderly: The Austrian Stroke Prevention Study
Neurology6 Jan 2016

Funding

3 grants since 2025

National Institute of Diabetes and Digestive and Kidney DiseasesUS$711.9kNational Institute on AgingUS$442.6kNational Heart, Lung, and Blood InstituteUS$422.9k