Executive function
Biomarker2 papers
- Humans1
- In silico1
Latest
24Epigenetic age links to higher dementia risk in older adults
In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia…In 2,606 participants, higher DunedinPACE was associated with increased risks of mild cognitive impairment (hazard ratio 1.16) and all-cause dementia (hazard ratio 1.30).
Severe infections and poor cognition link bidirectionally
Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk…Prior hospital-treated infection linked to lower general cognition (β = -0.11 SD), while each 1-SD higher cognitive score predicted a 36% lower risk of future infection.
Brainstem volume links to better memory in midlife
In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial…In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial stiffness.
Summary-level genetic method improves Alzheimer's risk prediction
The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve…The endoPRS-SS framework boosted computational efficiency up to 90-fold while using summary statistics and multiple endophenotypes to improve Alzheimer's disease risk prediction.
Visual search gaze patterns identify mild cognitive impairment
In 62 matched pairs, an expert 14-feature gaze panel classified mild cognitive impairment from cognitively normal aging with an area under the curve…In 62 matched pairs, an expert 14-feature gaze panel classified mild cognitive impairment from cognitively normal aging with an area under the curve of 0.898.
High neutrophil-to-lymphocyte ratio predicts cognitive decline
During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with…During five years of follow-up, 42.55% of older adults with high ratios progressed to mild cognitive impairment or dementia compared with 30.82% with normal ratios.
Tablet test detects cognitive impairment in older Ugandans
In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.