Skips

Papers on skips

178 papers13 new in 30 days

Tuesday, November 3

Diabetologia

Fatty liver genetic subtypes linked to opposite diabetes risks

An observational genetic analysis in UK Biobank participants linked fatty liver subtypes to higher or lower glucose and diabetes risk, with replication in a Chinese…An observational genetic analysis in UK Biobank participants linked fatty liver subtypes to higher or lower glucose and diabetes risk, with replication in a Chinese cohort.

Genetic association studyMechanisms

Friday, October 30

Monday, October 26

Sunday, October 25

Journal of Genetics and Genomics

Loss of an RNA regulator depletes egg reserves in animals

In an animal experiment, deleting an RNA-processing gene in egg cells caused complete female infertility and progressive depletion of the structures that house developing…In an animal experiment, deleting an RNA-processing gene in egg cells caused complete female infertility and progressive depletion of the structures that house developing eggs.

Animal studyMechanisms

Friday, October 23

Sunday, October 18

Friday, October 16

Wednesday, October 14

Nature Communications

TET2 loss alters DNA copying during drug treatment in cells

Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.Lab experiments showed that Olaparib treatment lengthened copied DNA tracts, increased DNA breaks and heightened drug sensitivity in cells lacking TET2, but not DNMT3A.

Loss of TET2, but not DNMT3A, increases fork progression and DNA damage in PARPi-treated cells.
Human cell studyTET2

Friday, October 9

Archives of Gerontology and Geriatrics

Depression linked to lower expected lifespan in older adults

In an observational study of 5,259 older adults in Thailand tracked for nine years, rising depressive symptoms predicted drops in how long they expected to live.In an observational study of 5,259 older adults in Thailand tracked for nine years, rising depressive symptoms predicted drops in how long they expected to live.

Cohort study of 5,259 peoplePopulations

Thursday, October 8

Monday, October 5

Monday, September 28

Thursday, September 24

Tuesday, September 15

Wednesday, August 26

Friday, August 21

Thursday, August 20

Nature

Lab-grown human brain models recorded developmental time

Human brain organoids grown for five years showed cell-type-specific changes in gene activity and DNA-based age estimates that tracked time in culture.Human brain organoids grown for five years showed cell-type-specific changes in gene activity and DNA-based age estimates that tracked time in culture.

Cortical organoids undergo progressive maturation during long-term culture.
Human cell studyMechanisms

Friday, August 14

Tuesday, August 11

Cell Press Blue

Disrupted immune signaling impairs B cell development in mice

Experiments in mice traced reduced B cell production to premature development, increased protein production and limited spare energy for cell expansion.Experiments in mice traced reduced B cell production to premature development, increased protein production and limited spare energy for cell expansion.

Experiments in miceNF-κB signaling

Thursday, August 6

Wednesday, August 5

Tuesday, August 4

Sunday, August 2

Tuesday, July 28

Saturday, July 18

Wednesday, July 15

Saturday, July 4