Pyruvate

8 papers2 findings

Human trial1
Humans4
Animals1

Effects

1

Cardiovascular disease

downin humans1

1 study

Pyruvate protects against cardiovascular disease in humans.
“pyruvate, alpha-ketobutyrate, and sarcosine all promoted oxidative phosphorylation, energy production, and protected against CVD development in Medalists.”
Humansin long-duration type 1 diabetes (Joslin Medalists)plasma
Cardiac Imaging and Metabolomics Suggest Distinct Cardioprotective and Risk Factors between Type 1 and Type 2 Diabetes
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Cardiovascular disease

Associations

1

Cognitive frailty

downin humans1

1 study

Pyruvate lowers the risk of cognitive frailty in humans (aRR = 0.94).
“one unit increment of baseline pyruvate Z-score was associated with attenuation in the progression to the next stage of cognitive frailty (aRR=0.94)”
Humanseight yearsn = 605
Association between metabolic profile and cognitive frailty in community-dwelling older adults: An eight-year cohort study
Mechanisms of ageing and development26 Nov 2025

More on Cognitive frailty

Funding

1 grant since 2023

National Institute of Diabetes and Digestive and Kidney DiseasesUS$36.1k

Muscle Mitochondrial Pyruvate Carrier Disruption Alters Amino Acid Metabolism to Maintain Muscle Mass During Recovery from Obesity
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of IowaUS$36.1k2021–2024

Latest

41 in 12 months

Cardiovascular Diabetology5 Oct

Integrated adipose tissue transcriptomic and miRNA remodeling identifies molecular pathways associated with residual cardiovascular risk after weight loss

Non-randomised trial in 66 peopleCardiovascular disease

bioRxiv21 Sep

MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease

Preprint: experiments in miceOxidative phosphorylation

Journal of Physiology and Biochemistry9 Sep

Hyperpolarized NMR study of the impact of alzheimer's disease on diabetes using a novel rat model

Experiments in ratsMechanisms

Frontiers in Nutrition4 Sep

EWAS in a polyphenol dense, DNA methylation-targeted, controlled diet and lifestyle study

Randomised trial in 38 peopleInterventions

Journal of Yeungnam Medical Science1 Sep

Metabolic sarcopenia in the era of incretin-based therapy: a narrative review of mitochondrial determinants of muscle quality and emerging therapeutic strategies

ReviewSarcopenia

The Journal of Physiology31 Aug

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early-life origin renal and metabolic dysfunction

Experiments in ratsKidney

Biology27 Aug

Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State

Computational studyNAD+ metabolism

Frontiers in Pharmacology25 Aug

Metabolic remodeling and cardiac functional adaptation mediated by dapagliflozin in patients with acute heart failure: a retrospective cohort study

Cohort study of 50 peopleDapagliflozin

Research21 Aug

PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence

Experiments in human cellsCellular senescence

Journal of Neurochemistry14 Aug

Estradiol Replacement Modulates Synaptic Transmission-Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Experiments in 18 ratsEstradiol