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Journal of Neurochemistry·Dec 4Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma ProteomeStudy in peopleMechanismsPaper
The Journal of Investigative Dermatology·Nov 28TGFα is required for hair follicle function during aging and its loss leads to progressive alopeciaExperiments in miceMechanismsPaper
Science·Nov 27Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regenerationExperiments in miceBones and jointsPaper
NPJ Science of Food·Nov 25B. adolescentis alleviates inflammation and suppresses PGE2 through remodling gut microbiota to attenuate pulmonary fibrosis in aging miceExperiments in micePulmonary fibrosisPaper
Frontiers in Aging·Oct 31Exploring the involvement of ferroptosis-associated genes and pathways in mesenchymal stem cell aging through bioinformatics analysisExperiments in cellsFerroptosisPaper
Frontiers in Endocrinology·Oct 30The role of bone-derived factors in bone and muscle communicationReviewBones and jointsPaper
Antioxidants·Oct 29Oxidative Stress, Inflammation, and Cellular Senescence in Neuropathic Pain: Mechanistic CrosstalkReviewOxidative stress and ROS signalingPaper
ENDO 2025 Abstract·Oct 23MON-317 Metabolomic signatures of lethal prostate cancer in pre-diagnosis serum samples from the Child Health and Development StudiesCohort study in peopleProstate cancerPaper
Annual Review of Pharmacology and Toxicology·Sep 19From Cell Reprogramming to Tissue Rejuvenation: Countering Aging by Targeting a GerozymeReviewInterventionsPaper
The Journal of Nutritional Biochemistry·Sep 11Urolithin A protects mice against osteoarthritis by inhibiting chondrocyte ferroptosis through activating AMPK/mTOR/HIF-1α signaling pathwayExperiments in miceUrolithin APaper
Stem Cells·Jul 315-PGDH inhibition enhances hematopoietic regeneration during agingExperiments in miceBlood and immune systemPaper
Reproductive Medicine and Biology·Jun 20Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASPReviewSenescence-associated secretory phenotype (SASP)Paper
Cell Stem Cell·Jun 14Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strengthExperiments in animalsMusclePaper
The Journal of Bone and Joint Surgery American Volume·Jun 6PGE2 Ameliorates Aging-Aggravated Rotator Cuff Muscle AtrophyExperiments in miceMusclePaper
Ecotoxicology and Environmental Safety·Jun 5Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathwayExperiments in mouse cellsOxidative stress and ROS signalingPaper
Biochimica et Biophysica Acta Molecular Cell Research·Jun 2MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validationExperiments in human cellsMitoQPaper
International Journal of Molecular Sciences·May 28Activating Transcription Factor 3 (ATF3) Regulates Cellular Senescence and Osteoclastogenesis via STAT3/ERK and p65/AP-1 Pathways in Human Periodontal Ligament CellsExperiments in human cellsCellular senescencePaper
Cell Host & Microbe·May 16Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axisExperiments in miceMicrobiome compositionPaper
bioRxiv·Apr 1715-PGDH inhibition promotes hematopoietic recovery and enhances HSC function during agingPreprint: experiments in miceBlood and immune systemPaper
Archives of Gerontology and Geriatrics·Mar 18FP receptor inhibits autophagy to aggravate aging-related cardiac fibrosis through PI3K/AKT/mTOR signaling pathwayExperiments in micePI3K–AKT signalingPaper
Experimental Gerontology·Feb 15Inhibition of 15-PGDH by SW033291 ameliorates age-related heart failure in miceExperiments in miceHeart failurePaper
Theranostics·Feb 3YAP1 mediates the dimensional and chemical coordination of immunoregulation and therapy in extensively passaged mesenchymal stem cellsExperiments in miceMesenchymal stem cellsPaper
Journal of Alzheimer's Disease·Jan 21Associations between dementia and exposure to topical glaucoma medicationsCohort study of 521 peopleGlaucomaPaper
Journal of Virology·Jan 17Prostaglandin D2 delays CD8+ T-cell responses and respiratory syncytial virus clearance in geriatric cotton ratsExperiments in animalsImmune responsePaper
GSA 2024 Abstract·Jan 1MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITYExperiments in miceMuscle weaknessPaper
Antioxidants·Dec 11Accelerated Sarcopenia Phenotype in the DJ-1/Park7-Knockout ZebrafishExperiments in zebrafishMusclePaper
Aging and Disease·Dec 10The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic TargetsReviewBones and jointsPaper
JCI Insight·Dec 6Activation of connexin hemichannels enhances mechanosensitivity and anabolism in disused and aged boneExperiments in miceBones and jointsPaper