MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITY

Abstract

Sarcopenia is an age-related disease that causes muscle weakness and reduced muscle quality with disproportionate impact on fast-twitch muscle. Gene expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme that metabolizes prostaglandins including PGE2, is elevated in older adult muscle and may contribute to sarcopenia.