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Friday, November 6

bioRxiv

Aging was most strongly linked to brain protein changes in mice

A laboratory analysis across the mouse lifespan linked aging to broader brain protein changes than amyloid-beta pathology, which modified selected age-related processes.A laboratory analysis across the mouse lifespan linked aging to broader brain protein changes than amyloid-beta pathology, which modified selected age-related processes.

Mouse brain tissue with branching neurons and mitochondria, with fewer inner folds and denser support cells near a dark plaque; a mouse sits below.
Preprint: mouse studyMechanisms
Paper
medRxiv

Kidney aging signs linked to faster decline in diabetic kidneys

In 24 people with diabetic kidney disease, higher tissue-aging scores were linked to faster kidney-function loss, with an adjusted correlation of -0.61.In 24 people with diabetic kidney disease, higher tissue-aging scores were linked to faster kidney-function loss, with an adjusted correlation of -0.61.

Kidney tissue with gaps between cells surrounds branching filters, beside a smaller gray tissue fragment with closely packed cells and loose cell rings.
Preprint: cohort · 24 peopleBiomarkers
Paper
Neurology Genetics

Sickle cell trait showed no clear link to stroke in adults

After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.After adjustment, adults with the trait had a relative hazard of 1.06 for strokes from blocked blood flow compared with adults without the variant.

Kaplan-Meier Cumulative Incidence Curves for Ischemic Stroke by HBB Genotype.
Cohort · 275,530 peopleSickle cell disease
Paper
Cancer Epidemiology, Biomarkers & Prevention

Urine profile linked to future cancer risk in healthy adults

Five-year cancer risk ranged from 0.18% in the lowest urine-score group to 32% in the highest.Five-year cancer risk ranged from 0.18% in the lowest urine-score group to 32% in the highest.

A long sugar molecule curves above a urine pool, flanked by gray human figures, with dark figures concentrated in the group on the right.
Cohort · 5,436 peopleCancer
Paper
BMC Geriatrics

Mental and movement training improved older adults’ leg strength

Chair-rise performance improved versus waitlist controls after 12 weeks, with a standardized effect size of 0.54 measuring the difference between groups.Chair-rise performance improved versus waitlist controls after 12 weeks, with a standardized effect size of 0.54 measuring the difference between groups.

Figure from BMC Geriatrics
Randomized trial in 50 peopleInterventions
Paper
Cell Death and Differentiation

Protein linked to bone-eroding cell formation in lab experiments

Cell experiments linked the protein to energy production and antioxidant regulation, two processes coordinated as bone-eroding cells develop.Cell experiments linked the protein to energy production and antioxidant regulation, two processes coordinated as bone-eroding cells develop.

Figure from Cell Death and Differentiation
Cell studyBones and joints
Paper
Metabolism

Blocking a brain signal restored activity in older mice

In mouse experiments, blocking serotonin, a brain signaling chemical, from acting in one brain region restored youthful activity levels and strength.In mouse experiments, blocking serotonin, a brain signaling chemical, from acting in one brain region restored youthful activity levels and strength.

Figure from Metabolism
Mouse studyMechanisms
Paper
Aging Cell

Immune and scar-related signals cluster in aging mouse hearts

Gene activity maps from 6- and 24-month-old mice pointed to valves and the aorta as major sites of age-related immune and scar-related changes.Gene activity maps from 6- and 24-month-old mice pointed to valves and the aorta as major sites of age-related immune and scar-related changes.

Figure from Aging Cell
Cross-sectional studyImmune response
Paper
Journal for ImmunoTherapy of Cancer

Exercise-linked blood proteins differ before cancer diagnosis

An observational analysis identified 52 proteins linked to exercise and to differences between healthy people and people who later received cancer diagnoses.An observational analysis identified 52 proteins linked to exercise and to differences between healthy people and people who later received cancer diagnoses.

Figure from Journal for ImmunoTherapy of Cancer
Cohort studyCancer
Paper