Polygenic risk

Biomarker

1 paper

  • Humans1

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iScience

Airborne benzene linked to fatty liver disease in UK adults

Each 0.151 microgram per cubic metre increase in residential benzene was associated with a 26% higher risk of developing non-alcoholic fatty liver disease.Each 0.151 microgram per cubic metre increase in residential benzene was associated with a 26% higher risk of developing non-alcoholic fatty liver disease.

Cohort study of 401,472 peoplePopulations
International Journal of Cancer

Bowel cancer risk estimates suggest tailored screening ages

Modelled ages ranged from before 40 for men with high genetic risk scores and family history to after 60 for women with low scores and no family history.Modelled ages ranged from before 40 for men with high genetic risk scores and family history to after 60 for women with low scores and no family history.

Cohort study of 353,118 peopleBiomarkers
medRxiv

Analysis links genetic heart disease risk to eight processes

An observational preprint identified eight genetic components and linked their risk scores to coronary artery disease in three large human biobanks.An observational preprint identified eight genetic components and linked their risk scores to coronary artery disease in three large human biobanks.

Preprint: cohort study of 458,905 peopleBiomarkers
Depression and Anxiety

Sleep-linked blood proteins associated with depression risk

Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.

Cohort study of 36,852 peopleDepression
Journal of the American Heart Association

Blood pressure gene scores linked to artery stiffness

An observational study of 5,804 people linked blood pressure gene scores to pressure-related artery stiffness, but not to structural stiffness associated with aging.An observational study of 5,804 people linked blood pressure gene scores to pressure-related artery stiffness, but not to structural stiffness associated with aging.

Cohort study of 5,804 peopleMechanisms
European Archives of Psychiatry and Clinical Neuroscience

Fine particle air pollution linked to higher dementia risk

In a prospective cohort followed for a median 11.9 years, 5,648 dementia cases were linked to particle pollution from domestic, transport and industrial sources.In a prospective cohort followed for a median 11.9 years, 5,648 dementia cases were linked to particle pollution from domestic, transport and industrial sources.

Cohort study of 5,648 peopleDementia
medRxiv

Polygenic risk links to disease burden and hospital use in Taiwan

In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.In a preprint, top-decile integrated genetic risk was linked to 23.9% more hospital days, and elevated diabetes risk corresponded to 1.50 lost healthy life-years.

Preprint: cohort study in peoplePopulations