PGC-1α

Biomarker

1 paper

  • Animals1

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Journal of Orthopaedic Translation

Low-intensity exercise eases age-related osteoarthritis in mice

In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.

Experiments in miceExercise
Signal Transduction and Targeted Therapy

Inotodiol preserves muscle mass and function in aged mice

The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.

Experiments in miceMuscle