In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.
Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.