Papers on osteogenic differentiation

703 papers45 new in 30 days

Monday, October 19

Journal of Cellular and Molecular MedicineOct 19

GPX4-Mediated Inhibition of Ferroptosis by Sodium Selenite Ameliorates Bone Metabolic Disorders in Ovariectomized Mice

Na₂SeO₃ promotes extracellular osteogenesis.

Experiments in miceBones and joints

Paper

Thursday, October 15

Advanced ScienceOct 15

Yoda1-Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Experiments in cellsBones and joints

Paper

European Journal of PharmacologyOct 15

Gut microbe products helped metformin protect bone in mice

Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.Experiments in mice with ovaries removed linked the drug’s bone benefits to short-chain fatty acids, small molecules made by gut bacteria.

Mouse studyMetformin

Paper

Life SciencesOct 15

Porphyromonas gingivalis lipopolysaccharide induces osteoblast senescence and defective mineralization associated with indoleamine 2,3-dioxygenase 1-kynurenine-aryl hydrocarbon receptor signaling

Experiments in human cellsTryptophan–kynurenine metabolism

Paper

Wednesday, October 14

Journal of Dental ResearchOct 14

GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence Gaps

ReviewGLP-1 receptor agonists

Paper

Materials Today BioOct 14

Bone-targeted drug delivery improves bone structure in mice

In mice lacking ovaries, the targeted carrier delivered raloxifene to bone tissue and improved bone formation and structural integrity compared with the free drug.In mice lacking ovaries, the targeted carrier delivered raloxifene to bone tissue and improved bone formation and structural integrity compared with the free drug.

Mouse studyBones and joints

Paper

Tuesday, October 13

BioMed Research InternationalOct 13

Effect of Maternal Age on the Proliferation and Osteogenic Differentiation of Human Umbilical Cord Stem Cells

Experiments in human cellsStem cell differentiation

Paper

Saturday, October 10

Advanced MaterialsOct 10

Silicate Biomaterials-Stimulated Vascularized Callus Organoids for Bone Tissue Regeneration

Experiments in ratsBones and joints

Paper

Chinese Journal of GerontologyOct 10

Mechanism by which dental pulp cell SASP mediates chronic fibrosis in aged dental pulp through the CCL5-CCR5 axis

Experiments in human cellsSenescence-associated secretory phenotype (SASP)

Paper

Thursday, October 8

Nano ResearchOct 8

Scaffold and metformin sped new bone formation in aged mice

A bone-supporting scaffold plus metformin accelerated new bone formation in aged mice, most clearly when bone-forming cells lacked a protein involved in energy…A bone-supporting scaffold plus metformin accelerated new bone formation in aged mice, most clearly when bone-forming cells lacked a protein involved in energy metabolism.

A thigh bone shows new growth bridging a porous scaffold, beside a smaller bone section with a wide unhealed gap and a mouse.

Experiments in miceMetformin

Paper

International Journal of Extreme ManufacturingOct 8

Customization of deformable devices with region-selectively assembled osteoinductive microrobots via 4D bioprinting for curved joint defect repair

Experiments in cellsBones and joints

Paper

Frontiers in Bioengineering and BiotechnologyOct 8

Dynamic microenvironments for bone organoids: spatiotemporal regulation of angiogenic-osteogenic coupling through advanced hydrogel design

Conceptual framework for dynamic hydrogel design in vascularized bone-organoid engineering.

ReviewBones and joints

Paper

International Journal of Extreme ManufacturingOct 8

Microbial biomanufacturing mineralized scaffolds with 3D bioprinting

Experiments in ratsInterventions

Paper

Tuesday, October 6

Journal of Pharmaceutical AnalysisOct 6

Mifepristone improved bone formation in mice with bone loss

In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow.In an experiment in mice with ovaries removed and fed a high-fat diet, the drug also reduced fat in bone marrow.

Experiments in miceBones and joints

Paper

Thursday, October 1

bioRxivOct 1

Cathelicidin peptide aids fracture healing in young mice but impairs it in aged mice

Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.Depleting Camp accelerated bone callus formation in aged mice while delaying repair in young mice through P2X7 receptor and NLRP3 signaling.

$Cathelicidin antimicrobial peptide is expressed at higher levels following fracture in young mice compared with aged mice.$

Preprint: experiments in miceBones and joints

Paper

Wednesday, September 30

Advanced Healthcare MaterialsSep 30

Coated implants improved bone attachment in osteoporotic rats

A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.

Experiments in ratsBones and joints

Paper

Tuesday, September 29

ACS Biomaterials Science & EngineeringSep 29

Bone-targeting particles improved bone structure in mice

An experiment in mice whose ovaries had been removed found that engineered, bone-targeting particles also reduced pain-related behaviors.An experiment in mice whose ovaries had been removed found that engineered, bone-targeting particles also reduced pain-related behaviors.

Bone sections beside laboratory mice show fragile gray struts against dense dark blue-green bone, with small cells and round particles by the stronger bone.

Experiments in miceBones and joints

Paper

Monday, September 28

Advanced ScienceSep 28

Puerarin-loaded nanoparticles improve bone mass in mice

In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.

Experiments in miceBones and joints

Paper

Advanced MaterialsSep 28

Bone-targeted exosomes delivering betaine reverse bone loss in osteoporotic rats

The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.

Experiments in ratsOsteoporosis

Paper

International Journal of Molecular SciencesSep 28

Characterization of Umbilical Cord Mesenchymal Stromal Cells Overexpressing Klotho and In Vitro Anti-Aging Efficacy of Their Derived Extracellular Vesicles

Preparation of Klotho-overexpressed UC-MSCs.

Experiments in human cellsInterventions

Paper

Saturday, September 26

BiomoleculesSep 26

Nuciferine reduces ovariectomy-induced bone loss in rats by activating autophagy

The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.The lotus leaf alkaloid promoted bone formation and osteogenic differentiation in ovariectomized rats through the TFEB autophagy-lysosomal pathway.