1 paper1 finding
Smoking initiation
upin humans1
Smoking initiation is associated with organ aging in humans.
“smoking initiation was positively linked to the aging of the lung, intestine, kidney, and stomach”
Humans
Revealing the genetic architectures underlying organ-specific aging based on proteomic data
Nature communications11 Dec 2025
Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.
In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several…In killifish experiments, lifelong mating reduced inflammation in old females’ main liver cells, while models based on gene activity predicted “younger” ages for several liver cell types.
In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.In UK Biobank participants, higher birthweight was associated with slower aging in 11 organs, while breastfeeding was linked to slower intestine and adrenal aging.
In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.
Four patterns captured most variation in connections across 438 brain regions and were reproducible across repeated scans and independent datasets.Four patterns captured most variation in connections across 438 brain regions and were reproducible across repeated scans and independent datasets.
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.