mtDNA mutation load

5 papers study it5 more mention it3 findings

Animals4
Cells1

Interventions

1

Exercise

downin mice1

1 study

Exercise decreases mtDNA mutation load in mice.
“decreasing the mtDNA mutation burden in muscle”
Animalsin mtDNA mutator micemuscle
Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice
Aging cellSep 6, 2019

More on Exercise

Upstream

1

POLG

upin pigs1

1 study

POLG increases mtDNA mutation load in pigs.
“These pigs exhibited elevated somatic mtDNA mutation loads”
Animalsproofreading-deficient POLG
Development of mitochondrial mutator pigs exhibiting increased mitochondrial DNA mutations and premature aging via prime editing
Science advancesAug 26, 2026

Associations

1

Individual iPSC lines and clonally expanded fibroblasts

upin human cells1

1 study

Individual iPSC lines and clonally expanded fibroblasts are associated with mtDNA mutation load in human cells.
“a panel of ten individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load of heteroplasmic or homoplasmic mutations”
Cellscompared with pooled skin and bloodiPSCs and clonally expanded fibroblasts
Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs
Cell stem cellApr 14, 2016

Latest

2 papers in 12 months

Science AdvancesAug 26

Development of mitochondrial mutator pigs exhibiting increased mitochondrial DNA mutations and premature aging via prime editing

Experiments in pigsMitochondrion

iScienceFeb 28

Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration

Experiments in miceOxidative phosphorylation

Aging CellOct 18

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice

Experiments in 4 miceSingle-cell omics

Communications BiologyOct 2

Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging

Experiments in miceOxidative stress and ROS signaling

Reproduction & FertilityAug 25

No evidence for age-related differences in mitochondrial RNA quality in the female germline

Experiments in animalsMechanisms

Aging CellSep 6

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

Experiments in miceExercise

ReproductionJun 6

Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse

Experiments in miceExercise

Nucleic Acids ResearchMay 11

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

Experiments in miceDNA repair

Current Opinion in Genetics & DevelopmentAug 9

Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis

ReviewInterventions

Cell Stem CellMay 8

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

Experiments in human cellsMitochondrion