There are 3 papers on mitochondria-derived reactive oxygen species in aging research: none in people yet, 1 in animals, 2 in cells.
3 papers study it7 more mention it3 findings
2 new papers in 30 daysSee all 10 papers on mitochondria-derived reactive oxygen species
- Animals1
- Cells2
Interventions
1Cathepsin b inhibitors
downin mouse cells1
1 study
Cathepsin b inhibitors
downin mouse cells1
Cathepsin b inhibitors decrease mitochondria-derived reactive oxygen species in mouse cells (induced by L-leucyl-L-leucine methyl ester).
“pharmacological inhibition of CatB significantly reduced the generation of mitochondria-derived ROS and proinflammatory mediators induced by L-leucyl-L-leucine methyl ester (LLOMe)”
Cellsinduced by L-leucyl-L-leucine methyl estermicroglia
Aging cell
Upstream
2PDK4
downin cells1
1 study
PDK4
downin cells1
PDK4 decreases mitochondria-derived reactive oxygen species in senescent cells, via inactivation of pyruvate dehydrogenase.
“which inactivates pyruvate dehydrogenase (PDH) and suppresses mitochondria-derived reactive oxygen species”
Cellsin senescent cells, via inactivation of pyruvate dehydrogenase
FEBS letters
SOD2 acetylation
is required forin cells1
1 study
SOD2 acetylation
is required forin cells1
SOD2 acetylation is required for mitochondria-derived reactive oxygen species in cells (site mutants of SOD2 acetylation sites).
“fisetin-induced mtROS were dependent on SOD2 acetylation”
Cellssite mutants of SOD2 acetylation sites
Phytotherapy research : PTR