There are 10 papers on SOD2 acetylation in aging research: 2 observational studies in people, 7 in animals, 1 in cells.
10 papers study it1 more mentions it4 findings
See all 11 papers on SOD2 acetylation
“Sirt3-dependent 3-fold increases in SOD2 acetylation”
- Humans2
- Animals7
- Cells1
Interventions
1Fisetin
upin cells1
1 study
Fisetin
upin cells1
Fisetin induces SOD2 acetylation in cells.
“fisetin disrupted mitochondrial homeostasis and induced SOD2 acetylation in PDAC”
Cells
Phytotherapy research : PTR
Effects
1Mitochondria-derived reactive oxygen species
is required forin cells1
1 study
Mitochondria-derived reactive oxygen species
is required forin cells1
SOD2 acetylation is required for mitochondria-derived reactive oxygen species in cells (site mutants of SOD2 acetylation sites).
“fisetin-induced mtROS were dependent on SOD2 acetylation”
Cellssite mutants of SOD2 acetylation sites
Phytotherapy research : PTR
Upstream
1SIRT2
downin cells1
1 study
SIRT2
downin cells1
SIRT2 decreases SOD2 acetylation in cells (shown by SIRT2 overexpression in fisetin-treated cells).
“SIRT2 overexpression could impede fisetin-induced SOD2 acetylation.”
Cellsshown by SIRT2 overexpression in fisetin-treated cells
Phytotherapy research : PTR
Associations
1Essential hypertension
upin humans1
1 study
Essential hypertension
upin humans1
Essential hypertension is associated with SOD2 acetylation in humans (Hypertensive subjects compared with normotensive subjects) (3-fold increase).
“Sirt3-dependent 3-fold increases in SOD2 acetylation”
HumansHypertensive subjects compared with normotensive subjectsarterioles from mediastinal fat
Circulation research
Funding
1 grant since 2021National Heart, Lung, and Blood Institute$2.4M