Microglial reactivity
1 paper1 finding
- Animals1
Interventions
1Mitophagy inducing compound
downin mice1
1 study
Mitophagy inducing compound
downin mice1
Mitophagy inducing compound decreases microglial reactivity in mice.
“3xTgAD mice fed an MIC-supplemented diet had a significant reduction in pTau accumulation and microglial reactivity”
Animals3xTgAD micebrainfrom age 4 months until 20 months on alternating weeks
GeroScience6 Mar 2026
Latest
7 in 12 monthsJournal of Neuroendocrinology
Periestropause enhances hypoxia-induced panic and microglial remodelling without altering respiratory control
Experiments in ratsMechanisms
iScience
Deletion of Snap25 disrupts glial remodeling in aging mouse brain
Experiments in animalsMechanisms
bioRxiv
Microbiome depletion rejuvenates the aging brain
Preprint: experiments in miceGut and microbiome
AAIC 2025 Abstract
Microglial reactivity attenuates ptau ₂₃₁ ‐related amyloid accumulation in preclinical Alzheimer's disease
Cohort study of 187 peopleMechanisms
AAIC 2025 Abstract
Core Activation Program and Selective Regional Responsiveness of Microglia in Aging and Parabiosis
Experiments in miceInflammation
AAIC 2025 Abstract
Microglial reactivity attenuates ptau ₂₃₁ ‐related amyloid accumulation in preclinical Alzheimer’s disease
Cohort study of 187 peopleMechanisms
Molecular Neurodegeneration
Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study
Cohort study in peopleSynapse
Journal of Leukocyte Biology
Suppression of NF-κB/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation
Experiments in animalsInterventions